The current study entitled "Study of Entrepreneurship and Employment in the Field of Knowledge-Based Businesses Based on Endowment Capacity" addresses one of the key issues in the field of business that can play an important role in resolving social, cultural and even political crises. The issue of employment has always been one of the biggest concerns of officials in various management levels of the country. The passage of various laws, and the formation of various working groups to solve the employment problem show the importance of the issue. One of the most important issues in job creation is the issue of investment. Limitations of government resources have always been a major challenge to resolving the employment crisis. In the meantime, some semi-governmental organizations and institutions, which have financial resources due to their duties and responsibilities, can help solve the problem. The Endowment and Charity Organization is one of these organizations. The research method in terms of purpose is of the type of applied research. Also, according to the research method, the present study is a mixed type (quantitative and qualitative). The statistical population in the qualitative section of the research is experts, specialists and pundits in various fields of management sciences, jurisprudence and Islamic economics and experts of the Endowment and Charity Organization in 1398 and 1399 in the country. The sampling method is purposeful and accessible. The statistical population will be in a small part to select the subjects by multi-stage cluster sampling method. The number of experts for polling in the Delphi method will be at least 20 experts, which will be done by purposeful sampling. The data collection method will be library and field using tools such as questionnaires and interviews with emphasis on the Delphi method. The technique of information analysis and modeling in this study will be Demitel, which has been used to identify the causal relationships between indicators in the subject of endowment investment in the fields of knowledge-based businesses and the production of a tangible structural model. The findings of this study show that in the test section of the model, the results show the effect of economic factors on knowledge-based businesses, especially the share and amount of non-cash income required by the business, the share and amount of cash income required by the business, the economic justification of the project, the amount of risk. The success of the project has the greatest impact on the organizational factors of knowledge-based businesses.